Projects

Research Projects

Our Sample Preparation Method:

Is simple and efficient

Requires only a magnet

Takes approximately 30 minutes with a hands-on time of 5 minutes

Is suitable for a variety of viruses

Is compatible with large serum or plasma samples

Results in isolated viruses or viral lysates that can be directly used for PCR

Projects Details:

FluSelect technology for Viable Flu Virus Isolation

Isolation and culture of flu viruses from animal samples are important for surveillance and
diagnosis of animal flu viruses. Similarly, isolation and concentration of flu viruses from human
clinical samples are also important for sensitive detection and effective surveillance of influenza.
We are developing a flu virus technology that is simple to use, and efficient for isolating and
concentrating flu viruses from samples. The recovered viruses are viable and can be used for
culturing and obtaining viral isolates. To learn more about it, please click on the title link.

V-Select technology for Rapid and Efficient Virus Isolation from Serum or Plasma Samples

Detection of viruses in serum or plasma samples involves cumbersome sample preparation. For
those samples with low virus concentration, it requires an additional ultracentrifugation step to
concentrate the viruses, or an expensive hybrid-capture approach to enrich nucleic acid. We are
developing a virus isolation technology, which can be used to rapidly and efficiently isolate and
concentrate virus from large-volume samples of serum or plasma (1-10 mL). The captured
viruses can be lysed and directly used for PCR, thus greatly simplifying the detection of viruses in
serum or plasma samples. To learn more about it, please click on the title link.

NA-Select Reagent for DNA Isolation from Highly Diluted and Complex Samples

Isolation of highly purified nucleic acids from diluted and/or dirty samples, e.g., soil, remains a
challenging task. This is because current nucleic acid isolation methods do not permit more
vigorous washing, which would be required to remove all contaminants. We have developed a
reagent that exhibits strong affinity for nucleic acids, thereby permitting rigorous washing of the
bound DNA and/or RNA. Because of this strong binding, the reagent is also very effective in
concentrating nucleic acids from highly diluted and large-volume (e.g., liters) samples. After being
released with an elution buffer, the nucleic acids can be directly used for downstream
applications such as PCR. To learn more about it, please click on the title link.

Acridinium NHS Ester and Other Acridinium Derivatives

Acridinium has been used as a highly sensitive chemiluminescent reagent for analyte detection in
diagnosis and research. When acridinium is used, the detection sensitivity rivals that of
radioisotopes. We have synthesized an array of acridinium derivatives, including NHS esters,
available for research or diagnostic use. To learn more about them, please click on the title link.